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“Now, we are 100 percent sure.” Because the capsid-associated tegument complex, or CATC, has unique characteristics compared to those in the other subfamilies, it likely plays a critical role in HSV-1’s unique life cycle.

By understanding the steps of this cycle through the structure, Zhou and his team gained deeper insight into how the virus infects, travels and persists in our nerve cells.

Zhou said scientists have published papers on the structures of tegument proteins for the past 20 years.

“But at lower resolutions, we didn’t know exactly what those molecules were until now,” he said.

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