Elucidating the role of androgen receptor in breast cancer

Six patients showed a complete or partial response (response rate of eight percent).

Elgene Lim has received grants from the National Breast Cancer Foundation, Australia, Victorian Cancer Agency, Australia, and the National Health and Medical Research Council, Australia.The effects of AR inhibition with Xtandi were examined in vitro and in preclinical models of ER-positive and ER-negative breast cancers with AR expression.The AR to ER ratio was an independent predictor of disease-free survival (HR, 4.04; 95 percent CI, 1.68-9.69; = .03).The androgen receptor (AR) is expressed in the majority of breast cancer and across the three main breast cancer subtypes.Historically, the oncogenic role of AR has best been described in molecular apocrine breast cancers, an estrogen receptor (ER)−/AR subtype which has a steroid response signature similar to that in the ER-positive breast cancer.

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