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In larger dosages, Kratom leaves are consider to have a sedative effect and can reduce feelings of anxiety and stress.
This is perhaps also why it has been used in the management of chronic pain.
Many of these are types of alkaloids such as mitraphylline and 7-hydroxymitragynine (which most people believe to be the primarily active ingredient).
One of the primary mechanisms of action for this supplement is by acting as an opioid receptor agonist like morphine.